Research technologies From A-Z A conversation with Roland Beckmann, inventor of the DutaMab technology Interview with Dutalys co-founder and inventor of the DutaMab technology platform, Roland Beckmann, on his invention and journey founding a biotech. more Analytics Analytics comprises a number of technologies that are deployed to characterize research compounds, active pharmaceutical ingredients as well as drug products. more Antibody Fusion Proteins Ban katantaAntibody Fusion Proteins are constructs that combine an antibody targeted to a specific antigen, typically a tumor-related antigen, with a protein that is able to amplify the immune response or induce direct damage to the cancer cell. more Antibody-Drug Conjugates Ban katantaAntibody-Drug Conjugates (ADCs) are a new class of highly potent biological drugs built by attaching a small molecule anticancer drug or another therapeutic agent to an antibody, with either a permanent or a labile linker. more Big Data Big Data is a term that has entered common use to refer to the amount, speed and diversity of data generated nowadays as a consequence of faster, more flexible and more pervasive data capture technology. more Biocatalysis Biocatalysis uses isolated enzymes or whole cells under mild conditions to catalyze and perform highly selective chemical reactions. more Bioinformatics Bioinformatics helps to process, analyze and interpret biological data and to automate analysis workflows, combining informatics tools and algorithms with a profound knowledge of the biological systems being analyzed. more Biomarkers Biomarkers is a word derived from “biological marker,” which indicates a substance or physical event that can be measured and correlated with health, disease or drug treatment. more Biosample Repository Biosample Repository is where samples collected during clinical studies or research on disease are stored and made available to Roche scientists. more Bispecific Antibodies Bispecific Antibodies combine two or more antigen-recognizing element into a single construct, able to bind to two or more targets. more Brain Shuttle Ban katantaBrain Shuttle is a technology that we have developed at Roche to increase penetration into the brain of large molecules such as antibodies. more Carcinogenicity Screening Ban katantaCarcinogenicity Screening is a very important element to guarantee the safety of potential drugs. more Chemical Biology Ban katantaChemical Biology comprises a range of activities where chemistry is deployed to create insight into biological processes at the molecular level. more Chemical Synthesis Ban katantaChemical Synthesis designs reliable and up-scalable syntheses for small molecules of interest, transforming research projects into robust manufacturing processes. more Clinical Pharmacology Clinical Pharmacology translates laboratory and animal data into clinical trials. more Compound Management Compound Management provides the infrastructure and logistics for the management of research compounds and supports the lead finding process in drug discovery. more CrossMAb Technology CrossMAbs are better accepted by the body 's immune system and have a reduced risk of immunogenic response compared to traditional bispecific antibodies. more Drug-Drug Interaction Ban katantaDrug-Drug Interaction can be a serious problem, as many diseases are treated with multiple medications. more Engineered for treatment success: Cytokine Fusion Proteins Ban katantaCytokine fusion proteins stimulate the immune system with high specificity and tolerability and could be a transformative approach to cancer treatment. more Formulation Formulation is at the core of transforming a bioactive molecule into a drug product. more Genetics and Genomics Ban katantaGenetics and Genomics is the study of the genome, i.e. all genes expressed in a cell, tissue, organism, or a sample of body fluids. more Glycoengineering Glycoengineering approaches generate new antibody variants with significantly enhanced capacity to recruit immune cells, like Natural Killer (NK) cells. more HTS Ban katantaHTS or High Throughput Screening is often the first step of a drug discovery endeavor. more Imaging Ban katantaImaging defines a number of technologies based on the generation and evaluation of images that provide information on the status of a physiological process in health and disease either in isolated cells, tissues or whole organisms. more In Silico PK/PD Modeling In Silico Modeling is deployed to predict how the pharmacology and pharmacokinetics of the drug as seen in laboratory and animals studies might translate to humans. more In Vivo Models In Vivo Models are a key component of the drug discovery value chain. more Locked Nucleic Acid (LNA) Platform Enabling scientists to develop a new class of medicines against diseases that are difficult, or impossible, to target with antibodies and small molecules. more MDO MDO means Multi-Dimensional Optimization. more Medicinal Chemistry Ban katantaMedicinal Chemistry is a highly interdisciplinary key science within pharmaceutical research, uniquely positioned at the interface to many other scientific areas. more Metabolite Identification Metabolite Identification deals with the potential safety issues associated with the breakdown products of a potential drug or any other substance which originates from the drug when the body interacts with it. more Molecular Modeling Ban katantaMolecular Modeling applies principles of computational chemistry to the interaction between a drug and its target, generally a protein. more Monoclonal Antibodies Monoclonal Antibodies (MAbs) are antibodies that are made by identical immune cells, cloned from a single parent cell. more Organs-on-a-Chip technology Ban katantaTiny labs made of plastic simulate the human body- the Organs-on-a-Chip technology shows new approaches to obtain human-relevant information on a potential drug. more Peptides Peptides are short sequences of amino acids and among the most potent bioactive substances known to man. more Pharmacokinetics Pharmacokinetics studies how organisms deal with a drug substance depending on its route of administration. more Phenotypic Screening Phenotypic Screening has been the basis for discovery of new drugs before the dawn of molecular biology. more Protein Production Protein Production requires the gene for the desired human protein to be inserted into an appropriate host cell. more Proteomics Proteomics is the study of all proteins expressed in a cell (tissue, organism, body fluids etc...), the so-called “proteome”. more Scientific Information Management Scientific Information Management guarantees that all our scientists get rapid access to all the newest information available in their field of interest. more Stem Cells Ban katantaStem Cells can differentiate into any cell types of the body. more Systems Biology Systems Biology is the attempt to integrate complex biological data into models that take the relevant interactions between the components of a living system into account. more Ten remarkable facts about making antibody medicines Antibodies are an important part of our immune system and antibody medicines can help fight diseases. Learn about the complex process needed to make them. more Teratogenicity Screening Teratogenicity Screening is a part of the panel of Reproductive Toxicology studies that look at potential adverse effects of a drug on fertility as well as the development of the embryo if the mother is exposed to the drug during pregnancy. more Toxicogenomics Toxicogenomics combines toxicology with genomics and tries to use the expression patterns of genes and proteins in cells to predict potential toxic effects of substances for which no reliable in vitro assay exists. more X-Ray Crystallography Ban katantaX-Ray Crystallography provides precise information on the tridimensional structure proteins and small molecules, allowing scientists to actually see the shape and conformational preference of the targets of interest. more
A conversation with Roland Beckmann, inventor of the DutaMab technology Interview with Dutalys co-founder and inventor of the DutaMab technology platform, Roland Beckmann, on his invention and journey founding a biotech. more
Analytics Analytics comprises a number of technologies that are deployed to characterize research compounds, active pharmaceutical ingredients as well as drug products. more
Antibody Fusion Proteins Ban katantaAntibody Fusion Proteins are constructs that combine an antibody targeted to a specific antigen, typically a tumor-related antigen, with a protein that is able to amplify the immune response or induce direct damage to the cancer cell. more
Antibody-Drug Conjugates Ban katantaAntibody-Drug Conjugates (ADCs) are a new class of highly potent biological drugs built by attaching a small molecule anticancer drug or another therapeutic agent to an antibody, with either a permanent or a labile linker. more
Big Data Big Data is a term that has entered common use to refer to the amount, speed and diversity of data generated nowadays as a consequence of faster, more flexible and more pervasive data capture technology. more
Biocatalysis Biocatalysis uses isolated enzymes or whole cells under mild conditions to catalyze and perform highly selective chemical reactions. more
Bioinformatics Bioinformatics helps to process, analyze and interpret biological data and to automate analysis workflows, combining informatics tools and algorithms with a profound knowledge of the biological systems being analyzed. more
Biomarkers Biomarkers is a word derived from “biological marker,” which indicates a substance or physical event that can be measured and correlated with health, disease or drug treatment. more
Biosample Repository Biosample Repository is where samples collected during clinical studies or research on disease are stored and made available to Roche scientists. more
Bispecific Antibodies Bispecific Antibodies combine two or more antigen-recognizing element into a single construct, able to bind to two or more targets. more
Brain Shuttle Ban katantaBrain Shuttle is a technology that we have developed at Roche to increase penetration into the brain of large molecules such as antibodies. more
Carcinogenicity Screening Ban katantaCarcinogenicity Screening is a very important element to guarantee the safety of potential drugs. more
Chemical Biology Ban katantaChemical Biology comprises a range of activities where chemistry is deployed to create insight into biological processes at the molecular level. more
Chemical Synthesis Ban katantaChemical Synthesis designs reliable and up-scalable syntheses for small molecules of interest, transforming research projects into robust manufacturing processes. more
Clinical Pharmacology Clinical Pharmacology translates laboratory and animal data into clinical trials. more
Compound Management Compound Management provides the infrastructure and logistics for the management of research compounds and supports the lead finding process in drug discovery. more
CrossMAb Technology CrossMAbs are better accepted by the body 's immune system and have a reduced risk of immunogenic response compared to traditional bispecific antibodies. more
Drug-Drug Interaction Ban katantaDrug-Drug Interaction can be a serious problem, as many diseases are treated with multiple medications. more
Engineered for treatment success: Cytokine Fusion Proteins Ban katantaCytokine fusion proteins stimulate the immune system with high specificity and tolerability and could be a transformative approach to cancer treatment. more
Formulation Formulation is at the core of transforming a bioactive molecule into a drug product. more
Genetics and Genomics Ban katantaGenetics and Genomics is the study of the genome, i.e. all genes expressed in a cell, tissue, organism, or a sample of body fluids. more
Glycoengineering Glycoengineering approaches generate new antibody variants with significantly enhanced capacity to recruit immune cells, like Natural Killer (NK) cells. more
HTS Ban katantaHTS or High Throughput Screening is often the first step of a drug discovery endeavor. more
Imaging Ban katantaImaging defines a number of technologies based on the generation and evaluation of images that provide information on the status of a physiological process in health and disease either in isolated cells, tissues or whole organisms. more
In Silico PK/PD Modeling In Silico Modeling is deployed to predict how the pharmacology and pharmacokinetics of the drug as seen in laboratory and animals studies might translate to humans. more
Locked Nucleic Acid (LNA) Platform Enabling scientists to develop a new class of medicines against diseases that are difficult, or impossible, to target with antibodies and small molecules. more
Medicinal Chemistry Ban katantaMedicinal Chemistry is a highly interdisciplinary key science within pharmaceutical research, uniquely positioned at the interface to many other scientific areas. more
Metabolite Identification Metabolite Identification deals with the potential safety issues associated with the breakdown products of a potential drug or any other substance which originates from the drug when the body interacts with it. more
Molecular Modeling Ban katantaMolecular Modeling applies principles of computational chemistry to the interaction between a drug and its target, generally a protein. more
Monoclonal Antibodies Monoclonal Antibodies (MAbs) are antibodies that are made by identical immune cells, cloned from a single parent cell. more
Organs-on-a-Chip technology Ban katantaTiny labs made of plastic simulate the human body- the Organs-on-a-Chip technology shows new approaches to obtain human-relevant information on a potential drug. more
Peptides Peptides are short sequences of amino acids and among the most potent bioactive substances known to man. more
Pharmacokinetics Pharmacokinetics studies how organisms deal with a drug substance depending on its route of administration. more
Phenotypic Screening Phenotypic Screening has been the basis for discovery of new drugs before the dawn of molecular biology. more
Protein Production Protein Production requires the gene for the desired human protein to be inserted into an appropriate host cell. more
Proteomics Proteomics is the study of all proteins expressed in a cell (tissue, organism, body fluids etc...), the so-called “proteome”. more
Scientific Information Management Scientific Information Management guarantees that all our scientists get rapid access to all the newest information available in their field of interest. more
Systems Biology Systems Biology is the attempt to integrate complex biological data into models that take the relevant interactions between the components of a living system into account. more
Ten remarkable facts about making antibody medicines Antibodies are an important part of our immune system and antibody medicines can help fight diseases. Learn about the complex process needed to make them. more
Teratogenicity Screening Teratogenicity Screening is a part of the panel of Reproductive Toxicology studies that look at potential adverse effects of a drug on fertility as well as the development of the embryo if the mother is exposed to the drug during pregnancy. more
Toxicogenomics Toxicogenomics combines toxicology with genomics and tries to use the expression patterns of genes and proteins in cells to predict potential toxic effects of substances for which no reliable in vitro assay exists. more
X-Ray Crystallography Ban katantaX-Ray Crystallography provides precise information on the tridimensional structure proteins and small molecules, allowing scientists to actually see the shape and conformational preference of the targets of interest. more
